SOMATIC TO PLURIPOTENT CONVERSION BY DECREASED pH
Hi everyone!
According to a recent research performed by Haruko et al., somatic cells can be converted into pluripotent cells by lowering the pH, that is, dipping them in acid. This procedure of reprogramming cells has been quoted as 'Stimulus-triggered acquisition of pluripotency' i.e. STAP.
As per the epigenetics, the pluripotent cells have the 'stemness' genes demethylated. The research reports that these reprogrammed cells showed a significant decrease in DNA methylation in the regulatory regions of pluripotency marker genes.
In addition, the injection of these cells into blastocysts generated chimeras via germline transmission. And, the derivation of expandable pluripotent cell lines has also been demonstrated.
Link to the article: http://www.nature.com/nature/journal/v505/n7485/full/nature12968.html
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