MORE VARIETY OF ORAL DRUGS FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS
1. Aubagio
Chemical name: Terifluonamide
Also known as: A77 1726
Mechanism of action: This chemical inhibits cells that proliferate rapidly by inhibition of dihydroorotate dehydrogenase (required by rapidly dividing cells). Also, Aubagio blocks the denovo pyrimidine synthesis and so, exerts a cytostatic effect on stimulated proliferation of T and B cells. Hence, it targets overreactive immune responses and avoids their migration into the central nervous system. It does not hamper or stop the pyrimidine salvage pathway and so, the functions of normal and slowly-dividing lyphocytes are maintained.
2. Tecfidera
Chemical Name: Dimethyl Fumarate
Mechanism of action: It is immuno-modulatory and also has anti-inflammatory properties. Hence, it induces the formation of anti-inflammatory cytokines. It may also have neuroprotective effects as it activates a substance critical for cellular damage/oxidative stress resistance.
These are both first line disease modifying drug therapies, which is good news
for those with relapsing/remitting MS!
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